INTROWelcome to our comprehensive guide on PreCardix®, a natural supplement that helps support healthy blood pressure and contribute to overall cardiovascular and heart health. In this guide, we'll explore the unique features and potential benefits of PreCardix®, delve into the scientific research backing its ingredients, and provide insights into how it can complement a heart-healthy lifestyle.

1. Introduction to PreCardix®

In today’s fast-paced world, maintaining heart health is a top priority for many individuals. As cardiovascular conditions remain a significant global health concern, more people are seeking safe, natural ways to support their overall cardiovascular well-being and promote long-term vitality in a proactive way.

PreCardix® is a natural health supplement that helps maintain healthy blood pressure levels and support overall heart health. Licensed as a Natural Health Product in Canada, PreCardix® meets the rigorous safety and quality standards established for natural health products.

With its unique natural ingredient, bioactive marine peptides, PreCardix® offers a complementary approach to heart health. Its formulation focuses on supporting key factors affecting cardiovascular function, making it a potential option for those seeking to maintain heart health naturally as part of a balanced lifestyle.


2. Benefits and Uses

Understanding the potential benefits and applications of PreCardix® is key to appreciating how it supports cardiovascular health. Below, we explore what sets this natural supplement apart:

Key Benefits

  • Helps Maintain Healthy Blood Pressure Levels: PreCardix® is formulated to support blood pressure within the normal range, which is an important factor in reducing risks associated with elevated blood pressure.
  • Promotes Circulation: By supporting healthy blood vessel function, PreCardix® may contribute to circulatory health and efficient blood flow.
  • Natural, Safe and Well-Tolerated: Made with premium natural ingredients, with safety and efficacy supported by clinical research, PreCardix® provides an option for individuals seeking proactive and alternative support for cardiovascular health.
  • Supports Overall Heart Health: Regular use of PreCardix® can contribute to maintaining cardiovascular wellness, helping support heart function as part of a balanced lifestyle.

How PreCardix® Works

PreCardix® is a natural health supplement formulated with bioactive marine peptides derived from shrimp shells (Pandalus borealis). These peptides are studied for their potential to support cardiovascular health.. 

The research into PreCardix® has also explored the mechanisms by which its bioactive marine peptides support cardiovascular health:

  • ACE inhibition: These peptides are associated with the inhibition of the Angiotensin-Converting Enzyme (ACE), a key regulator of blood pressure.
  • Arterial Flexibility and Blood Flow: By reducing the production of angiotensin II, PreCardix®’s bioactive marine peptides may help support nitric oxide availability, a molecule critical for vascular health. This process promotes the relaxation and flexibility of blood vessels, contributing to healthy circulation.
  • Fluid Balance: The peptides’ primary mechanism of action may also support healthy sodium and water balance by influencing pathways related to aldosterone, reducing strain on the cardiovascular system.

These mechanisms are part of a holistic approach to cardiovascular wellness, aligning with PreCardix®’s role in supporting overall heart health.

3. Research and Studies

Scientific research forms the backbone of PreCardix®’s credibility and effectiveness. Let’s delve into the studies that support its use.

Clinical Trials and Findings

The science behind PreCardix® is grounded in high-quality clinical research that explores its role in maintaining cardiovascular health. The studies specifically focus on the ability of its patented bioactive marine peptides to inhibit the angiotensin-converting enzyme (ACE), a key enzyme in cardiovascular regulation. While individual responses may vary, the rigorous research provides a strong foundation for PreCardix® as a trusted option for those seeking natural cardiovascular support.

MARE Study (Marine Peptide Study)

The MARE study was the first clinical investigation into the bioactive marine peptides derived from shrimp shell protein hydrolysate, the key ingredient in PreCardix®. This study not only explored the safety and cardiovascular health benefits of the peptides but also played a critical role in determining the therapeutic dose needed to achieve their effects.

  • Purpose: The primary objectives of the MARE study were to assess the safety profile of the bioactive marine peptides, evaluate their potential role in supporting blood pressure maintenance and overall cardiovascular wellness, and establish the appropriate therapeutic dose. 
  • Highlights: The study demonstrated a favorable safety profile, with no significant adverse effects, and provided initial evidence of the peptides’ potential to support cardiovascular health. Importantly, it identified the optimal dosage required to maximize their benefits, laying the groundwork for subsequent clinical trials.

This early research was pivotal in defining the safe and effective use of marine peptides, setting the stage for larger, more comprehensive trials that would further evaluate their role in supporting cardiovascular wellness.

The study further elucidated the mechanism behind PreCardix®’s efficacy, showing a significant reduction in angiotensin II levels, which correlates with its ACE inhibitory effects.*

* Musa-Veloso K, Paulionis L, Pelipyagina T, Evans M. A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. Int J Hypertens. 2019;2019:2345042. Published 2019 Aug 5. doi:10.1155/2019/2345042.

Gold-Standard Multicentre Clinical Study

Building on the MARE study, a larger, randomized, double-blind, placebo-controlled trial was conducted to further evaluate the potential of shrimp-derived peptides in cardiovascular health.

  • Purpose: This multicentre trial expanded the scope of research, examining how these unique peptides may contribute to maintaining healthy blood pressure in a broader population.
  • Design: The study followed rigorous clinical standards to assess safety and the role of these peptides in supporting cardiovascular function over an 8-week period.

This research reinforced PreCardix®’s potential as a natural health product, contributing to the body of evidence supporting its use for proactive heart care.

Mechanism of Action and Key Insights

The clinical studies primarily assessed the ability of PreCardix®’s bioactive marine peptides to inhibit ACE, a central mechanism in cardiovascular health. This mechanism is the foundation of PreCardix®’s Health Canada-approved health claims. While these studies did not directly evaluate downstream effects, the ACE-inhibiting mechanism of action is closely linked to two critical pathways that influence cardiovascular health:

1) ACE Inhibition and the RAAS Pathway

    • ACE converts angiotensin I into angiotensin II, a compound that raises blood pressure by constricting blood vessels and stimulating the release of aldosterone, a hormone responsible for sodium and water retention.
    • By inhibiting ACE, the peptides in PreCardix® reduce angiotensin II production, supporting blood vessel relaxation and potentially reducing the strain on the heart by decreasing blood pressure.

2) ACE Inhibition and the NO Pathway

    • Angiotensin II can reduce the availability of nitric oxide (NO), a molecule essential for vascular health. NO promotes blood vessel relaxation (vasodilation) and efficient blood flow.
    • By lowering angiotensin II levels, ACE modulation helps preserve NO availability, encouraging healthy circulation and supporting vascular flexibility.

3) Interconnection of Pathways: Promoting Circulation and Fluid Balance

    • The reduction in aldosterone, triggered by lower angiotensin II levels, helps regulate sodium and water balance. This contributes to fluid balance and reduces blood volume, further alleviating cardiovascular strain.
    • Together, these effects—NO-enhanced vasodilation, reduced vascular resistance, and improved fluid regulation—may contribute to maintaining healthy blood pressure and overall cardiovascular wellness.

Conclusion

The clinical studies behind PreCardix® provide evidence for its ACE-inhibiting mechanism of action, which is fundamental to its role in supporting cardiovascular health. While the research specifically measured ACE activity, this mechanism is intrinsically linked to pathways that influence nitric oxide availability, vascular flexibility, and fluid balance.

Backed by clinical studies and a growing body of evidence, PreCardix® provides consumers with confidence in its potential to complement a heart-healthy lifestyle.

4. Product Comparisons

Understanding how PreCardix® stacks up against other heart health solutions is essential for making informed choices.

PreCardix® vs. Other Natural Supplements

Feature

PreCardix®

Other Natural Health Products Derived from Natural Sources

Key Ingredient

Unique, patented bioactive marine peptides (Shrimp-derived)

Often a blend of various ingredients, sometimes without patent or unique formulation

Scientific Backing

Supported by clinical studies published in peer-reviewed journals

Often lacks rigorous clinical trials, relying on anecdotal evidence

Mechanism of Action

Specifically targets ACE modulation, a well-documented pathway for blood pressure regulation

Mechanisms often unclear or based on generalized assumptions about ingredients

Therapeutic Dose

Each daily dose contains 1200 mg of bioactive peptides, consistent with the amount studied in clinical trials

Many products do not provide research-validated dosing

Efficacy

Demonstrated significant benefits for blood pressure health in clinical trials

Efficacy varies widely and is often unproven due to insufficient evidence, on insufficient dosing

Quality Standards

Adheres to strict quality control processes with batch testing for bioactivity, effect, and quality by third-party labs

Quality varies significantly between brands and formulations

Safety Profile

High safety profile, documented through clinical trials

Safety profiles often unclear or poorly documented

Regulatory Approval

Approved by Health Canada, FDA, and EFSA

May not have specific regulatory approvals or certifications

Consumer Trust

Transparency in ingredient sourcing and scientific backing fosters high trust

Consumer trust varies, often reliant on brand reputation

Recommended by Health Care Professionals

Backed by a medical advisory board; recommended by nutritionists and health professionals

Professional endorsements vary; may not have formal recommendations

Summary: PreCardix® stands out in the natural health supplement market due to its patented bioactive ingredient, robust scientific validation, and adherence to therapeutic dosing established in clinical trials. These attributes, coupled with strict quality controls and regulatory approvals, make PreCardix® a reliable choice for those seeking natural support for cardiovascular health. As always, consult a healthcare provider to determine if PreCardix® is suitable for your individual needs.

5. Customer Testimonials

4.8+

Average rating on Amazon Canada

"After struggling with slightly elevated blood pressure for years, I decided to give PreCardix® a try. Within a few weeks, I noticed a significant improvement. My blood pressure readings are now consistently within the normal range, and I feel more energetic than ever. I love that it's a natural product without any side effects!"

Sarah L.

"PreCardix® has been a game-changer for me. Not only has it helped manage my blood pressure, but I've also noticed better overall wellness. My doctor is impressed with the improvements, and I highly recommend this supplement to anyone concerned about their heart health."

Mark D.

"I started taking PreCardix® as a proactive measure since heart disease runs in my family. It's comforting to know that I'm supporting my cardiovascular health naturally. The supplement is easy to incorporate into my daily routine, and I haven't experienced any adverse effects."

Emily S.

6. Usage Guidelines

To achieve optimal results and ensure safety, proper usage of PreCardix® is essential. Below are detailed guidelines on how to incorporate this supplement into your health regimen.

Dosage Recommendations

  • Recommended Dose: Adults: Take two tablets together daily, preferably away from meals to enhance absorption.
  • Duration: Allow up to 8 weeks (2 packs) to achieve results and continue to take daily to maintain results.
  • Tip! Taking the capsules tablets in the morning is recommended for consistent support throughout the day.

Who May Benefit from PreCardix®

  • Health-Conscious Individuals: Those looking for natural options to help support their cardiovascular health as part of a proactive wellness routine.
  • Individuals Seeking to Maintain Healthy Blood Pressure: For those aiming to support healthy blood pressure levels naturally.
  • People Interested in Supporting Cardiovascular Wellness: Individuals with lifestyle factors or family history that may influence heart health.
  • Those Exploring Natural Health Products: Individuals seeking scientifically studied, natural options as part of their overall health strategy.

 

Potential Side Effects and Precautions

PreCardix® has not had any serious side effects reported. It has not been found to cause side effects sometimes associated with ACE inhibitor medication such as dry cough, itching, edema (swelling), high potassium levels, or hypotension (low blood pressure). Some users may experience mild digestive discomfort such as moderate nausea, bloating, or stomach discomfort upon introduction. These effects are typically temporary and resolve as the body adjusts.

Cautions and Warnings:

  • Consult a health care practitioner prior to use if:
    • You are taking blood pressure medication or blood thinners
    • You are taking medication 
    • You have a medical condition
    • You are planning a medical procedure
    • You are pregnant or breastfeeding
    • Hypersensitivity / allergy has been known to occur with shellfish, in which case, discontinue use

    PreCardix® is not appropriate for: 

    • Children under 18 years old
    • People who have a history of angioedema related to the use of ACEI medication
    • People with renal artery stenosis

7. Frequently Asked Questions

Here you’ll find some of the typical questions we get asked from our customers. For a comprehensive list of questions and answers about all PreCardix, click here to read our FAQ.

Yes, PreCardix® is formulated with natural ingredients and is safe for long-term use when taken as directed. However, it’s advisable to have periodic consultations with your healthcare provider to monitor your health status.

You should consult your healthcare provider before combining PreCardix® with any prescription medications to ensure safety and avoid potential interactions.

Individual results may vary, but many users report noticeable improvements in blood pressure and overall well-being within 4-8 weeks of consistent use.

While taking PreCardix®, maintaining a balanced diet rich in fruits, vegetables, whole grains, and lean proteins can enhance its effectiveness. Limiting sodium intake and staying hydrated are also beneficial for heart health.

PreCardix® can be purchased through official retailers including Amazon.ca, authorized pharmacies, and the official website to ensure authenticity and quality.

8. Conclusion

In conclusion, PreCardix® offers a natural option for individuals seeking to support cardiovascular health and maintain healthy blood pressure levels. Its scientifically studied formulation and high safety profile make it a promising addition to a heart-healthy lifestyle.

Whether you are looking to proactively maintain your cardiovascular health or complement an existing wellness routine, PreCardix® provides a supportive option grounded in emerging scientific research and user satisfaction.

Consider consulting a healthcare provider to determine if PreCardix® is right for you as you take meaningful steps toward prioritizing your heart health and overall well-being.

With PreCardix®, you take a proactive step towards a life of vitality and longevity.

Important Information

Always consult with your healthcare provider before making changes to your blood pressure management plan. PreCardix® does not treat, cure, or prevent medical conditions. Measure and monitor blood pressure regularly. Know the signs of heart attack and stroke.

Do not take PreCardix® if you are pregnant, breastfeeding, have renal artery stenosis, have a history of angioneurotic edema, or have a shellfish allergy. Consult product guidelines for additional information. Print and share the product monograph with your healthcare provider.

PreCardix® is an innovation of Marealis Inc. a Norwegian Bio-Tech company dedicated to finding natural, sustainable, and effective marine-based solutions for blood pressure health, globally. Designed in Norway. Manufactured in North America.

Rune Larsen